Rheumatoid Arthritis Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component. INHERITANCE Occasional families show a considerable number of cases of this common disorder. A simple Mendelian mechanism could not be proved, however. Indeed, some (Burch et al., 1964) could not rise significant familial aggregation. Lynn et al. (1995) conducted family studies and segregation analyses of RA based on consecutive patients with RA determine without regard to family history or known adventure factors.
Included in the analyses were first- degree relatives from 135 unidirectional and 30 multiplex families. A highly penetrate recessionary major gene, with a mutant allele frequency of 0.005, was aim as the most parsimonious genetic fortune factor. evidential evidence for heterogeneity in risk for RA was ascertained for proband gender but not for proband age at onset. Kaplan-Meier risk analysis demonstrated significant evid...If you want to get a full essay, order it on our website:
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